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Treatment Resistant Schizophrenia
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Nervous System Disorders
Question #11719
45 days ago
153

Treatment Resistant Schizophrenia - #11719

Rishabh

Hello, It all Started in 2015, when I started feeling stressed with exams.started with antidepressants but it took a long route. I started getting hallucinations of my college enemies in my ears and many other fears of numbers.Doctor said that u r hullcianting & getting fears.From 10 years I am on antipsychotics.NowI am taking Amisulpride 300mg & Clozapine 25 mg at night. But still they areoccupied with occasional hulluci Nation. Please give medication which can cure it totally because I am taking it from 10 years. In 10 years I have seen many voices in my ears and also vivid dreams at night. How to cure Schizophrenia totally by medicine Because I am sick of medicine taking for 10 years.

Mental health
300 INR (~3.53 USD)
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Doctors’ responses

Dr. Abhishek Gill
I am a doctor with 5 years total experience, mostly split between Emergency and Obstetrics & Gynaecology—and honestly both keep you on your toes in totally different ways. In the ER, you don’t get time to second-guess much. Things come at you fast—trauma, active bleeding, breathlessness, collapsed vitals—and you learn to think, act, then think again. But in Obs/Gyn, it’s more layered. One moment you’re handling routine antenatal care, the next you're managing obstructed labour at 3am with everything depending on timing. I try not to treat anyone like "just another case." I take proper history—like actual, detailed listening—and then move step by step. Exam, investigations only if needed (not just because), and explaining things clearly to the patient and attenders. Not gonna lie, sometimes I do repeat myself twice or thrice. People are stressed, they don’t hear it all the first time. Communication I’d say is one of my stronger areas, but not in some fancy textbook way. Just knowing *how* to talk, when to pause, when not to overload info. Like with a first-time mother in pain who doesn’t care about medical terms—she just wants to know if her baby’s okay. Those moments taught me more about medicine than most of my exams. I handle postpartum issues, early pregnancy complications, PCOD, menstrual complaints, emergency contraception consults too—bit of everything. And in casualty shifts, I’ve done everything from inserting Ryle’s tubes to managing hypertensive crises. You have to stay sharp. But also know when to slow down and re-evalutate something that doesn’t fit right. Counselling’s part of the job too. Sometimes patients need reassurance more than a prescription. Sometimes they just need honesty, even if the answer isn't simple. I don’t pretend to have all the answers, but I do care enough to find them. Bit by bit. Every single day.
43 days ago
5

hello Rishabh, Your symptoms are chronic and persistent.

For best management, I suggest you to visit the PSYCHIATRIST in person.

Meanwhile, 1. Continue your prescribed medicines 2. Start Behavioural therapy sessions 3. Adequate sleep 4. Balanced diet

Take care

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Dr. Arsha K Isac
I am a general dentist with 3+ years of working in real-world setups, and lemme say—every single patient teaches me something diff. It’s not just teeth honestly, it’s people… and how they feel walking into the chair. I try really hard to not make it just a “procedure thing.” I explain stuff in plain words—no confusing dental jargon, just straight talk—coz I feel like when ppl *get* what's going on, they feel safer n that makes all the difference. Worked with all ages—like, little kids who need that gentle nudge about brushing, to older folks who come in with long histories and sometimes just need someone to really sit n listen. It’s weirdly rewarding to see someone walk out lighter, not just 'coz their toothache's gone but coz they felt seen during the whole thing. A lot of ppl come in scared or just unsure, and I honestly take that seriously. I keep the vibe calm. Try to read their mood, don’t rush. I always tell myself—every smile’s got a story, even the broken ones. My thing is: comfort first, then precision. I want the outcome to last, not just look good for a week. Not tryna claim perfection or magic solutions—just consistent, clear, hands-on care where patients feel heard. I think dentistry should *fit* the person, not push them into a box. That's kinda been my philosophy from day one. And yeah, maybe sometimes I overexplain or spend a bit too long checking alignment again but hey, if it means someone eats pain-free or finally smiles wide in pics again? Worth it. Every time.
43 days ago
5

Hello Rishabh,

It can often be managed very well with the right combination of medication, therapy, lifestyle, and support.

My advice: Ask your psychiatrist about dosage of your drug. Don’t medicate yourself, should be supervised by your doctor.

Consider CBT for Psychosis (CBT-P) -A special therapy to help manage voices and reduce distress.

Improve Lifestyle for Brain Health; Regular sleep, exercise, no drugs/alcohol, and supplements like Omega-3.

Please consult your concerned doctor for a re evaluation.

Feel free to talk I trust this helps Thank you

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Dr. Nirav Jain
I am a qualified medical doctor with MBBS and DNB Diploma in Family Medicine from NBEMS, and my work has always been centered on treating patients in a complete, not just symptom based way. During my DNB training I rotated through almost every core department—Internal medicine, Pediatrics, Obstetrics & Gynecology, Surgery, Orthopedics, ENT, Dermatology, Psychiatry, Emergency medicine. That mix gave me the skill to manage acute illness, long term disease and preventive care together, something I find very important in family practice. In psychiatry I worked closely with patients who struggled with depression, anxiety, stress related problems, insomnia or substance use. I learned not just about medication but also about simple psychotherapy tools, psycho education and how to talk openly without judgement. I still use that exp in family medicine, specially when chronic disease patients also face mental health issues. My time in General surgery included assisting in minor and major procedures, managing wounds, abscess, sutures and emergencies. While I am not a surgeon, this gave me confidence to recognize surgical cases early, provide first line care and refer fast when needed, which makes a big difference in online or OPD settings. Now I work as a consultant in General medicine and Family practice, with focus on both in-person and online consultation. I treat conditions like fever, infections, gastrointestinal complaints, respiratory illness, and also manage diabetes, hypertension, thyroid disorders, and lifestyle related chronic diseases. I see women for PCOS, contraception counseling, menstrual health, and children for common pediatric issues. I also dedicate time to preventive health, lifestyle counseling and diet-sleep-exercise advice, since these small changes affect long term wellness more than we often realize. My key skills include holistic diagnosis, evidence based treatment, chronic disease management, mental health support, preventive medicine and telemedicine communiation. At the center of all this is one thing—patients should feel heard, safe, and guided with care that is both professional and personal.
41 days ago
5

Hello Rishabh, you’ve been through a long, exhausting journey - 10 years on treatment is a heavy load. I’m really sorry you’re still having symptoms. You need to understand your disease well, see, Schizophrenia is not a completely curable condition, but with time people improve and after a long symptom free period, the medications can be gradually reduced in number. Clozapine is probably the only anti-psychotic medicine with proven superior benefit for your condition. Here is my advise for you -

1. Do not stop your current meds abruptly. It will worsen your situation . Kindly consult your treating psychiatrist regarding dosage adjustments, it’ll help you a lot.

2. Get done these tests - Plasma Clozapine Levels, CBC, Thyroid Profile, FBS, Lipid Profile, LFT, RFT, ECG.

3. You should consider ECT, kindly discuss this with your Psychiatrist as well. This helps in treatment resistant cases.

4. These are some non-drug treatments that help - -CBT for psychosis (CBTp) — helps reduce distress from voices and improves coping. -Hearing voices groups / peer support — many find these helpful. -Occupational rehabilitation, vocational support, family psychoeducation — crucial for functional recovery.

Regards, Dr. Nirav Jain MBBS, DNB D.Fam.Med

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Dr. Bharat Joshi
I’m a periodontist and academician with a strong clinical and teaching background. Over the last 4 years and 8 months, I’ve been actively involved in dental education, guiding students at multiple levels including dental hygienist, BDS, and MDS programs. Currently, I serve as a Reader at MMCDSR in Ambala, Haryana—a role that allows me to merge my academic passion with hands-on experience. Clinically, I’ve been practicing dentistry for the past 12 years. From routine procedures like scaling and root planing to more advanced cases involving grafts, biopsies, and implant surgeries. Honestly, I still find joy in doing a simple RCT when it’s needed. It’s not just about the procedure but making sure the patient feels comfortable and safe. Academically, I have 26 research publications to my credit. I’m on the editorial boards of the Archives of Dental Research and Journal of Dental Research and Oral Health, and I’ve spent a lot of time reviewing manuscripts—from case reports to meta-analyses and even book reviews. I was honored to receive the “Best Editor” award by Innovative Publications, and Athena Publications recognized me as an “excellent reviewer,” which honestly came as a bit of a surprise! In 2025, I had the opportunity to present a guest lecture in Italy on traumatic oral lesions. Sharing my work and learning from peers globally has been incredibly fulfilling. Outside academics and clinics, I’ve also worked in the pharmaceutical sector as a Drug Safety Associate for about 3 years, focusing on pharmacovigilance. That role really sharpened my attention to detail and deepened my understanding of drug interactions and adverse effects. My goal is to keep learning, and give every patient and student my absolute best.
44 days ago
5

Hello dear See you are already on medication since 10 years I can suggest some change of medication along with precautions In addition please get latest following tests to see the current status Pet Mri Ct scan CBC if recommended Eeg Follow below instructions Do meditation for mental health Exercises regularly for physical freshness Engage in social activities for mind engagement Indulge in hobbies like reading novels or writing for bringing self confidence Take balanced diet Take zincovit multivitamin therapy once a day for 1 month Avoid alcohol or smoking if taking already Avoid junk food You may be given following medications if neurosurgeon or psychiatrist Risperidone Chlorpromazine Please share the details with neurologist or psychiatrist Please donot take any medications without consulting the concerned doctor Hopefully you recover soon Regards

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Dr. Shayeque Reza
I completed my medical degree in 2023, but honestly, my journey in healthcare started way before that. Since 2018, I’ve been actively involved in clinical practice—getting hands-on exposure across multiple departments like ENT, pediatrics, dermatology, ophthalmology, medicine, and emergency care. One of the most intense and defining phases of my training was working at a District Government Hospital for a full year during the COVID pandemic. It was chaotic, unpredictable, and exhausting—but it also grounded me in real-world medicine like no textbook ever could. Over time, I’ve worked in both OPD and IPD setups, handling everything from mild viral fevers to more stubborn, long-term conditions. These day-to-day experiences really built my base and taught me how to stay calm when things get hectic—and how to adjust fast when plans don’t go as expected. What I’ve learned most is that care isn't only about writing the right medicine. It’s about being fully there, listening properly, and making sure the person feels seen—not just treated. Alongside clinical work, I’ve also been exposed to preventive health, health education, and community outreach. These areas really matter to me because I believe real impact begins outside the hospital, with awareness and early intervention. My approach is always centered around clarity, empathy, and clinical logic—I like to make sure every patient knows exactly what’s going on and why we’re doing what we’re doing. I’ve always felt a pull towards general medicine and internal care, and honestly, I’m still learning every single day—each patient brings a new lesson. Medicine never really sits still, it keeps shifting, and I try to shift with it. Not just in terms of what I know, but also in how I listen and respond. For me, it’s always been about giving real care. Genuine, respectful, and the kind that actually helps a person heal—inside and out.
43 days ago
5

I know 10 years on medicines is exhausting but there are concrete, evidence-based steps that improve outcomes for many people: ensure clozapine is at a therapeutic dose/level, monitor safely, consider augmentation/ECT if needed, and add psychosocial treatments. Many patients do substantially better when these steps are applied systematically sometimes to the point of long remissions

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Dr. Alan Reji
I'm Dr. Alan Reji, a general dentist with a deep-rooted passion for helping people achieve lasting oral health while making dental visits feel less intimidating. I graduated from Pushpagiri College of Dental Sciences (batch of 2018), and ever since, I've been committed to offering high-quality care that balances both advanced clinical knowledge and genuine compassion for my patients. Starting Dent To Smile here in Palakkad wasn’t just about opening a clinic—it was really about creating a space where people feel relaxed the moment they walk in. Dental care can feel cold or overly clinical, and I’ve always wanted to change that. So I focused on making it warm, easygoing, and centered completely around you. I mix new-age tech with some good old-fashioned values—really listening, explaining stuff without jargon, and making sure you feel involved, not just treated. From regular cleanings to fillings or even cosmetic work, I try my best to keep things smooth and stress-free. No hidden steps. No last-minute surprises. I have a strong interest in patient education and preventive dentistry. I genuinely believe most dental issues can be caught early—or even avoided—when patients are given the right information at the right time. That’s why I take time to talk, not just treat. Helping people understand why something’s happening is as important to me as treating what’s happening. At my practice, I’ve made it a point to stay current with the latest innovations—digital diagnostics, minimally invasive techniques, and smart scheduling that respects people’s time. I also try to make my services accessible and affordable, because good dental care shouldn’t be out of reach for anyone.
43 days ago
5

Schizophrenia is usually a long-term condition, and medicines like clozapine or amisulpride help control symptoms but rarely cure it completely. If hallucinations persist, your psychiatrist can review clozapine dosage, check blood levels, or consider augmentation strategies and non-medication therapies like CBT for psychosis. Please consult a psychiatrist (preferably in a tertiary care center) for a detailed treatment review and second-opinion on advanced options.

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For schizophrenia, especially when it’s treatment resistant, it’s crucial to work closely with a psychiatrist who’s experienced in managing the condition. While medication is a central component in managing symptoms, a “cure” may not be immediately possible. You mentioned you’re taking Amisulpride and Clozapine. These are effective antipsychotics but may need adjustments or augmentation with other treatments for better control of symptoms. Treatment-resistant schizophrenia sometimes benefits from dose adjustments, combination therapy, or even trying a different antipsychotic. Clozapine, in particular, often requires careful monitoring due to potential side effects, but it’s typicaly reserved for treatment-resistant cases because of its efficacy. Have you discussed with your psychiatrist the issue of dosage optimization? Sometimes small adjustments or even the addition of adjunct medications, like mood stabilizers or selective serotonin reuptake inhibitors, might improve your response. It would also be wise to consider non-pharmacological treatments. These can include cognitive-behavioral therapy tailored for schizophrenia, which can help manage hallucinations and delusional thoughts. Participating in psychosocial support programs can also offer substantial benefits by improving overall function and social skills, which medications alone cannot address. Another aspect that sometimes helps is a review of your overall lifestyle and health. Ensure you’re receiving adequate rest, proper nutrition, and engaging in regular physical activity, as these can all contribute to overall mental well-being. Additionally, some patients benefit from techniques like mindfulness or stress reduction exercises. Discuss with your treating physician if there may be secondary conditions or lifestyle factors that might influence your symptoms. It’s important not to stop medications without professional guidance, as doing so could potentially worsen symptoms. Regular follow-ups and open communication with your healthcare provider are paramount in effectively managing schizophrenia long-term.

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