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Struggling to Conceive After 11 Months With PCOS Despite Letrozole Treatment
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Question #21115
3 hours ago
15

Struggling to Conceive After 11 Months With PCOS Despite Letrozole Treatment - #21115

Ashna

We have been trying to conceive for 11 months and I am not pregnant yet. I have PCOS. I take myo-d-chiro inositol every day as prescribed by my doctor in India. From the 2nd to the 6th day of my period, I take letrozole 5 mg, as prescribed. I am currently abroad and have taken letrozole for four months, but I am still not pregnant. What should I do now?

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Doctors’ responses

Dr. Bharat Joshi
I’m a periodontist and academician with a strong clinical and teaching background. Over the last 4 years and 8 months, I’ve been actively involved in dental education, guiding students at multiple levels including dental hygienist, BDS, and MDS programs. Currently, I serve as a Reader at MMCDSR in Ambala, Haryana—a role that allows me to merge my academic passion with hands-on experience. Clinically, I’ve been practicing dentistry for the past 12 years. From routine procedures like scaling and root planing to more advanced cases involving grafts, biopsies, and implant surgeries. Honestly, I still find joy in doing a simple RCT when it’s needed. It’s not just about the procedure but making sure the patient feels comfortable and safe. Academically, I have 26 research publications to my credit. I’m on the editorial boards of the Archives of Dental Research and Journal of Dental Research and Oral Health, and I’ve spent a lot of time reviewing manuscripts—from case reports to meta-analyses and even book reviews. I was honored to receive the “Best Editor” award by Innovative Publications, and Athena Publications recognized me as an “excellent reviewer,” which honestly came as a bit of a surprise! In 2025, I had the opportunity to present a guest lecture in Italy on traumatic oral lesions. Sharing my work and learning from peers globally has been incredibly fulfilling. Outside academics and clinics, I’ve also worked in the pharmaceutical sector as a Drug Safety Associate for about 3 years, focusing on pharmacovigilance. That role really sharpened my attention to detail and deepened my understanding of drug interactions and adverse effects. My goal is to keep learning, and give every patient and student my absolute best.
1 hour ago
5

Hello dear See as per history it can be concluded that you can wait for sometime. Sometimes pregnancy are conceived in 6-9 th ovulation cycle In addition there may be some hidden markers like Tsh Vitamin d Lh level Progesterone level. Please share the result of these tests with gynecologist in person to rule out other possible reasons I suggest you donot immediately stop medication Consult with your gynecologist for medication dose reduction or modification

In addition Please avoid Junk food Heavy meals Hormonal therapy Hopefully iam clear with your query Regards

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Dr. Shayeque Reza
I completed my medical degree in 2023, but honestly, my journey in healthcare started way before that. Since 2018, I’ve been actively involved in clinical practice—getting hands-on exposure across multiple departments like ENT, pediatrics, dermatology, ophthalmology, medicine, and emergency care. One of the most intense and defining phases of my training was working at a District Government Hospital for a full year during the COVID pandemic. It was chaotic, unpredictable, and exhausting—but it also grounded me in real-world medicine like no textbook ever could. Over time, I’ve worked in both OPD and IPD setups, handling everything from mild viral fevers to more stubborn, long-term conditions. These day-to-day experiences really built my base and taught me how to stay calm when things get hectic—and how to adjust fast when plans don’t go as expected. What I’ve learned most is that care isn't only about writing the right medicine. It’s about being fully there, listening properly, and making sure the person feels seen—not just treated. Alongside clinical work, I’ve also been exposed to preventive health, health education, and community outreach. These areas really matter to me because I believe real impact begins outside the hospital, with awareness and early intervention. My approach is always centered around clarity, empathy, and clinical logic—I like to make sure every patient knows exactly what’s going on and why we’re doing what we’re doing. I’ve always felt a pull towards general medicine and internal care, and honestly, I’m still learning every single day—each patient brings a new lesson. Medicine never really sits still, it keeps shifting, and I try to shift with it. Not just in terms of what I know, but also in how I listen and respond. For me, it’s always been about giving real care. Genuine, respectful, and the kind that actually helps a person heal—inside and out.
18 minutes ago
5

You have PCOS and have been trying to conceive for 11 months. You are taking myo-inositol and D-chiro-inositol daily and letrozole 5 mg from day 2 to day 6 of your cycle for ovulation induction. You have taken letrozole for 4 cycles but have not achieved pregnancy yet.

Summary:

You are following standard PCOS fertility management.

Not conceiving after 4 cycles of letrozole is common, as it does not guarantee pregnancy in every cycle.

Next steps usually include:

Evaluation of ovulation response – your doctor may check whether ovulation occurred with letrozole using ultrasound or hormone tests.

Dose adjustment – some women may need higher doses of letrozole (7.5–10 mg) if ovulation is not occurring. Alternative medications – sometimes clomiphene citrate, gonadotropins, or combination therapy are used.

Partner evaluation – sperm testing should be done if not already done.

Lifestyle optimization – maintaining healthy weight, diet, exercise, and stress management helps PCOS fertility.

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