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Seeking Medication Recommendations for Depression and Sexual Side Effects
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Mental & Emotional Health
Question #27023
16 days ago
69

Seeking Medication Recommendations for Depression and Sexual Side Effects - #27023

Client_7f6068

I thank all the doctors here who have taken time to reply to my first inquiry earlier. I'm planning on seeing a psychiatrist again to help with my low mood and depression. I already saw one and was given trimipramine that helped me a lot with my anger crisis but didn't help at all lifting my mood from the total depression controlling my life. trimipramine have sexual side effects that are still lingering after years from finishing the course. I didn't do testosterone levels but there rest of my blood work is okay (normal cbc, thyroid function, fasting glucose, kidneyfunction, heart health ...etc)... I am asking for recommendations from you of medication that I can ask the psychiatrist for that should help lift my depression and mood and maybe reverse the sexual side effects of trimipramine if you could recommend anything. Thanks and I am grateful in advance for your support

How long have you been experiencing low mood and depression?:

- More than 6 months

Have you experienced any specific triggers for your low mood?:

- No specific triggers

What other treatments have you tried for your depression?:

- Therapy (e.g., CBT)
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Doctors' responses

Dr. Arsha K Isac
I am a general dentist with 3+ years of working in real-world setups, and lemme say—every single patient teaches me something diff. It’s not just teeth honestly, it’s people… and how they feel walking into the chair. I try really hard to not make it just a “procedure thing.” I explain stuff in plain words—no confusing dental jargon, just straight talk—coz I feel like when ppl *get* what's going on, they feel safer n that makes all the difference. Worked with all ages—like, little kids who need that gentle nudge about brushing, to older folks who come in with long histories and sometimes just need someone to really sit n listen. It’s weirdly rewarding to see someone walk out lighter, not just 'coz their toothache's gone but coz they felt seen during the whole thing. A lot of ppl come in scared or just unsure, and I honestly take that seriously. I keep the vibe calm. Try to read their mood, don’t rush. I always tell myself—every smile’s got a story, even the broken ones. My thing is: comfort first, then precision. I want the outcome to last, not just look good for a week. Not tryna claim perfection or magic solutions—just consistent, clear, hands-on care where patients feel heard. I think dentistry should *fit* the person, not push them into a box. That's kinda been my philosophy from day one. And yeah, maybe sometimes I overexplain or spend a bit too long checking alignment again but hey, if it means someone eats pain-free or finally smiles wide in pics again? Worth it. Every time.
15 days ago
5

Hello

Ask your psychiatrist about: • Bupropion → lifts mood, very low sexual side effects, may improve sexual function • Vortioxetine → effective for depression with low sexual side effects • Mirtazapine → good for mood + sleep, minimal sexual effects

If another antidepressant is used, adding low-dose bupropion can reduce sexual side effects.

Also consider testosterone check and hormone review.

Review of current stress, sleep, and overall health — improving depression itself often improves sexual function.

You can say: “I need an antidepressant that lifts mood but minimizes sexual side effects — could we consider bupropion, vortioxetine, or an add-on strategy?”

I trust this helps Thank you Take care

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Dr. Bharat Joshi
I’m a periodontist and academician with a strong clinical and teaching background. Over the last 4 years and 8 months, I’ve been actively involved in dental education, guiding students at multiple levels including dental hygienist, BDS, and MDS programs. Currently, I serve as a Reader at MMCDSR in Ambala, Haryana—a role that allows me to merge my academic passion with hands-on experience. Clinically, I’ve been practicing dentistry for the past 12 years. From routine procedures like scaling and root planing to more advanced cases involving grafts, biopsies, and implant surgeries. Honestly, I still find joy in doing a simple RCT when it’s needed. It’s not just about the procedure but making sure the patient feels comfortable and safe. Academically, I have 26 research publications to my credit. I’m on the editorial boards of the Archives of Dental Research and Journal of Dental Research and Oral Health, and I’ve spent a lot of time reviewing manuscripts—from case reports to meta-analyses and even book reviews. I was honored to receive the “Best Editor” award by Innovative Publications, and Athena Publications recognized me as an “excellent reviewer,” which honestly came as a bit of a surprise! In 2025, I had the opportunity to present a guest lecture in Italy on traumatic oral lesions. Sharing my work and learning from peers globally has been incredibly fulfilling. Outside academics and clinics, I’ve also worked in the pharmaceutical sector as a Drug Safety Associate for about 3 years, focusing on pharmacovigilance. That role really sharpened my attention to detail and deepened my understanding of drug interactions and adverse effects. My goal is to keep learning, and give every patient and student my absolute best.
15 days ago
5

Hello dear See improvement will occur but it will require time Iam suggesting some methods for improvement Please follow them for atleast two months Do physical exercise atleast half an hour daily for 5 months Do meditation Take good balanced diet for good health Engage in social media Indulge in hobbies like reading and writing Avoid overthinking Avoid junk food and alcohol/ smoking Set your goals for every day Hopefully improvement will occur In case of no improvement in 2 month consult psychiatrist in person for better clarity Regards

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While it’s good that you’re planning to speak with a psychiatrist, it’s important to tailor any medication to your specific need and symptoms, considering the complete context of your health. In terms of managing depression while minimizing sexual side effects, there are a few avenues you might consider discussing with your psychiatrist. SSRIs, like escitalopram or sertraline, are commonly used, but they can also occasionally affect sexual function. If they haven’t been effective or tolerated before, you could consider SNRIs like venlafaxine, which some people tolerate better in terms of sexual health. Bupropion is another option that is often noted for having a lower risk of sexual side effects and may even improve them. It works differently than SSRIs and SNRIs and could be beneficial for mood and energy improvement. Since you’ve had a history with trimipramine, which is a tricyclic antidepressant, it’s good you’ve noticed what didn’t work well and to see new options. Detailed conversation with your psychiatrist is key here to balance efficacy, side effect profile and any personal history with medication. Also, think about discussing lifestyle elements that help support medication like regular exercise, fair sleeping patterns, and nutritional considerations. Monitoring testosterone could be reasonable as part of investigating sexual health concerns, given your history. Finally, adjusting or changing medications should always be done with guidance from your healthcare provider to account for unique responses and potential interactions.

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