Loose diarrhea post colonoscopy damage - #10437
I am a 20-year-old patient experiencing chronic rectal leakage and burning sensation since a colonoscopy performed a few months ago. The leakage is watery or mucous-like, worsens with food or abdominal pressure, and causes severe discomfort. MRI abdomen showed congested mesenteric vessels, but no active inflammation or major pathology. Colonoscopy report did not reveal ulceration or colitis. I have already tried Loperamide, Sucralfate, dietary changes, and probiotics, but there has been no relief. Symptoms continue even without any supplements or triggers. No history of endocrine tumors, infection, or systemic illness. This seems to be a post-procedural secretory gut dysfunction, possibly due to mucosal irritation or neurogenic overactivity. The issue is disabling and affects my daily functioning. Request: I am requesting a trial of Octreotide under supervision to help reduce abnormal intestinal secretions. I am open to other healing agents like L-Glutamine, Sucralfate, or Clonidine, if appropriate. I am willing to follow strict monitoring and local follow-up care as advised. This is not stress-related — I am sincerely seeking a treatment-based solution for persistent gut leakage.
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Doctors’ responses
Hello dear Please be aware I think this is due to side-effects or post operative complications after colonoscopy You can try loperamide once a day and flagyl for immediate relief But better consult the surgeon for clarification Regards
You are not alone or misinterpreting the issue. This is a known but under-recognized complication post-colonoscopy, likely due to disruption of gut neuroendocrine signaling.
A trial of Octreotide + L-glutamine + Clonidine is medically justifiable and should be initiated by a licensed physician under monitoring.
Your description suggests a persistent secretory dysfunction or neurogenic gut overactivity post-colonoscopy, especially with MRI showing mesenteric congestion. Octreotide may indeed help reduce abnormal secretions in such cases, but it requires specialist approval and close monitoring. Consult a gastroenterologist to evaluate suitability for Octreotide, and discuss adjuncts like L-Glutamine, Clonidine, or bile acid binders for symptom control and mucosal healing.
Your situation seems quite complex, given the persistent symptoms and how extensively you’ve already explored initial interventions. The chronic leakage and burning sensation you describe could indeed be related to post-procedural changes in gut function. Considering your symptoms and the findings from your MRI, there’s a possibility of dysregulated intestinal secretion or motility that’s not clearly visible on standard imaging or endoscopy.
Given that Loperamide and dietary modifications have not provided relief, it’s reasonable to consider other therapeutic avenues. Octreotide, an analog of somatostatin, can help reduce secretions and slow gut motility in certain cases, like neurogenic overactivity or other dysregulations of the gastrointestinal tract. However, it’s typically reserved for more specific conditions, so it would be crucial to have thorough evaluation and monitoring by a gastroenterologist experienced with its use and potential side effects.
Alternative suggestions like L-Glutamine and Clonidine have varying degrees of supportive evidence for managing GI dysfunction related to post-procedural changes. L-Glutamine could, potentially, support mucosal healing, but its efficacy specifically after colonoscopy is not well-established. Clonidine might help if there’s a neurogenic component, as it can modulate sympathetic activity affecting gut function, though its use would similarly require close supervision.
If Octreotide is being considered, it’s important this decision is made collaboratively with your healthcare provider. Ensure you’re in a setting where side effects can be promptly identified and managed, as it can affect glucose metabolism and other bodily systems. It can also cause GI side effects initially, so an informed discussion with your care team about risk-benefit balance and expectations is crucial. Keeping a symptom diary could additionally aid healthcare providers in tailoring your treatment plan more effectively for future consultations. Transitioning this plan in conjunction with targeted testing or additional symptomatic evaluations might provide more insights into your condition.
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