Regarding side effect of Pregabalin and nortrityline - #14781
Hii doctors My question is regarding Side effect of Pregabalin 50 mg and nortriptyline 10 mg . Does these medication cause sexual side effect like Decreased Libido and erection problems like achieving and maintaning erection. If these medication cause these side effect then how long these effect will last after stoping medications.
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Doctors’ responses
Hello Tara By going through your history and evaluation of your health status I must say that Yes both drugs Pregabalin and Nortriptyline can have side effects, and sexual side effects are indeed possible with these medications. *Pregabalin: This medication is often used for nerve pain and anxiety. Some people report experiencing decreased libido or difficulties with erections while on it. *Nortriptyline: As a tricyclic antidepressant, it can also lead to sexual side effects, including decreased libido and issues with achieving or maintaining an erection.
*Duration of Side Effects: - The duration of these side effects after stopping the medications can vary from person to person. Generally, once the medications are discontinued, side effects may start to improve within a few days to weeks, but it can take longer for some individuals.
But before discontinuing consult with your previous doctor as he/she can guide you on the best approach and monitor any withdrawal symptoms.
Thank you
Hello Tara, I understand your concern and here is my advise -
1. Yes, sometimes Pregabalin & Nortriptyline can cause decreased libido, not in everyone though, and rarely erectile problems. But you don’t have to worry as with a good approach these issues are fully reversible.
2. In most people, sexual side effects improve gradually within 1–3 weeks after stopping the medicines.
3. What to do next - -Don’t stop the medicines abruptly, discuss with your prescribing doctor first. -If sexual side effects are significant: The doctor may reduce the dose or switch to an alternative. -Lifestyle measures: regular exercise, stress control, and good sleep, these help restore libido faster.
Feel free to reach out again.
Regards, Dr. Nirav Jain MBBS, DNB D.Fam.Med
The potential for sexual side effects does exist with both pregabalin and nortriptyline, though it tends to be relatively less common than with some other medications. Pregabalin can, in some cases, cause decreased libido or erectile dysfunction, but this isn’t typically listed among the most frequent side effects. Nortriptyline, however, as a tricyclic antidepressant, is more commonly associated with sexual side effects, including decreased libido and erectile difficulties. The duration for which these effects might persist after discontinuing the medications can vary greatly. Some individuals may notice an improvement in a few days to weeks, while for others, it might take longer. If you’re experiencing these side effects, it’s essential to speak with your healthcare provider before making any changes to your medication regimen. They can help assess whether your symptoms are indeed linked to the medication, and discuss possible alternatives or supportive treatments. Sometimes, the solution may involve adjusting the dosage, switching medications, or incorporating treatments specifically for the sexual side effects. The key is engaging in an open dialogue with your treatment provider to ensure your overall health and treatment goals are being met.
Hello dear See both these any epileptic medication do cause weight gain and generalised swelling. However loss of libido and sexual erection are less noticed as per clinical research Usually the effects should go within 2-3 months maximum to 6 after stopping medication However sudden withdrawal can cause more side-effects so slow tapering is recommended as per recommendation by concerned physician Hopefully iam clear with your doubts Regards
Hello Tara,
Answers to your questions:
1.Yes, both can occasionally cause these side effects. 2.Don’t worry, they usually resolve within days to weeks after stopping.
In rare cases, symptoms may persist longer, especially if another cause (like anxiety, depression, or another medication) contributes.
There’s no known permanent sexual dysfunction reported from pregabalin or nortriptyline after discontinuation.
So please don’t adjust your medication on your own.
It will improve within a few days to a few weeks after stopping.👍
I hope I solved your concern Thank you
If you’re currently experiencing these side effects
Do not stop the medicine suddenly This can cause withdrawal symptoms, mood issues, rebound pain.
Instead: Talk with your doctor They can reduce dose or switch to alternatives (like Duloxetine, Gabapentin, Amitriptyline adjustments, etc.)
Sometimes adding:
B-vitamins Exercise Managing anxiety can also help improve sexual function.
I want to know that these medication really cause these symptoms or causing only in my case. Or i have another reason.
Yes, both Pregabalin (50 mg) and Nortriptyline (10 mg) can cause sexual side effects, including reduced libido and difficulty achieving or maintaining erections, because they affect the nervous system and certain neurotransmitters. Not everyone experiences this, but when it happens, the effect usually improves gradually after stopping the medication, typically within 2–6 weeks, depending on how long you were taking them. If symptoms persist or the medication is still needed for pain or nerve issues, please consult a Neurologist or Psychiatrist to adjust the dose or switch to a drug with fewer sexual side effects.
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