Reason for raised ALP, with no liver abnormality - #19306
Patient has history of hysterectomy and cholecystectomy and previous 2 times drug induced jaundice before these surgeries ,Now All parameters of LFT are normal except ALP which is rising and is now800, CT and MRCP shows liver hemangiomas with irregular liver margins and no blockage to any duct what can be the cause of this countinuous rising
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Doctors’ responses
Hello ,
Most likely causes Non-liver (bone) source – common Vitamin D deficiency, osteomalacia, Paget’s disease, hyperparathyroidism
Early autoimmune cholestatic liver disease Especially Primary Biliary Cholangitis (PBC)
Chronic drug-induced cholestasis (given past history)
hemangiomas do not usually cause high ALP
Key tests needed GGT (normal = bone source; high = liver source) ALP isoenzymes (if available) Vitamin D, calcium, phosphate, PTH AMA, ANA, IgM Fibroscan
Persistent isolated ALP elevation is most often from bone disease or early cholestatic liver disease. Further targeted testing is essential to identify the source.
I trust this helps Thank you
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