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Reason for raised ALP, with no liver abnormality
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General Health
Question #19306
3 hours ago
11

Reason for raised ALP, with no liver abnormality - #19306

Sonia

Patient has history of hysterectomy and cholecystectomy and previous 2 times drug induced jaundice before these surgeries ,Now All parameters of LFT are normal except ALP which is rising and is now800, CT and MRCP shows liver hemangiomas with irregular liver margins and no blockage to any duct what can be the cause of this countinuous rising

Age: 47
Chronic illnesses: No
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Doctors’ responses

Dr. Arsha K Isac
I am a general dentist with 3+ years of working in real-world setups, and lemme say—every single patient teaches me something diff. It’s not just teeth honestly, it’s people… and how they feel walking into the chair. I try really hard to not make it just a “procedure thing.” I explain stuff in plain words—no confusing dental jargon, just straight talk—coz I feel like when ppl *get* what's going on, they feel safer n that makes all the difference. Worked with all ages—like, little kids who need that gentle nudge about brushing, to older folks who come in with long histories and sometimes just need someone to really sit n listen. It’s weirdly rewarding to see someone walk out lighter, not just 'coz their toothache's gone but coz they felt seen during the whole thing. A lot of ppl come in scared or just unsure, and I honestly take that seriously. I keep the vibe calm. Try to read their mood, don’t rush. I always tell myself—every smile’s got a story, even the broken ones. My thing is: comfort first, then precision. I want the outcome to last, not just look good for a week. Not tryna claim perfection or magic solutions—just consistent, clear, hands-on care where patients feel heard. I think dentistry should *fit* the person, not push them into a box. That's kinda been my philosophy from day one. And yeah, maybe sometimes I overexplain or spend a bit too long checking alignment again but hey, if it means someone eats pain-free or finally smiles wide in pics again? Worth it. Every time.
2 hours ago
5

Hello ,

Most likely causes Non-liver (bone) source – common Vitamin D deficiency, osteomalacia, Paget’s disease, hyperparathyroidism

Early autoimmune cholestatic liver disease Especially Primary Biliary Cholangitis (PBC)

Chronic drug-induced cholestasis (given past history)

hemangiomas do not usually cause high ALP

Key tests needed GGT (normal = bone source; high = liver source) ALP isoenzymes (if available) Vitamin D, calcium, phosphate, PTH AMA, ANA, IgM Fibroscan

Persistent isolated ALP elevation is most often from bone disease or early cholestatic liver disease. Further targeted testing is essential to identify the source.

I trust this helps Thank you

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