What is the best home treatment for my mother with Chronic Myeloid Leukemia and a UTI? - #30354

Dear Doctors, I am writing to seek your expert medical opinion regarding my mother Age: 55 years. She has been recently diagnosed with a blood disorder, and I wanted to share her complete case history, diagnostic reports, and the newly started treatment protocol for your review and guidance. 1. Primary Diagnosis: Chronic Myeloid Leukemia - Chronic Phase (CML - CP) Associated with UTI and high-grade fever. 2. Complete Diagnostic Findings: BCR-ABL1 (Quantitative): P210 (b3a2, b2a2) major transcript Detected. The IS Score is 35.1798%. Bone Marrow Aspiration & Biopsy: Hypercellular marrow (nearly 100% cellularity). Blasts at 02% (no increase in blasts). Final Impression: Suggestive of/Compatible with CML-CP. CBC Profile: WBC count was around 50,000 and Platelets were highly elevated (> 16 Lakhs). Cultures (Dated 19 May): Blood Culture is NEGATIVE (No organism grown after 72 hrs). Urine Culture is NEGATIVE (No organism grown after 24 hrs). Note: Initial urine routine showed 30-40 pus cells. KFT (Dated 17 May): Creatinine is perfectly normal at 0.66. Uric Acid is 3.45. LFT (Dated 17 May): SGOT (19.1) and SGPT (29.2) are normal. Alkaline Phosphatase is slightly elevated at 134, along with mildly high direct bilirubin. Ultrasound/Stone: She had a 3.1 mm renal stone which caused severe renal colic, but the stone has passed and the abdominal pain is now completely resolved. 3. Current Clinical Symptoms: Fever: Persistent low-grade to high-grade tumor fever (around 100°F) with occasional severe chills/shivering at night. Bowel Movements: Currently experiencing watery loose motions with some mucus, likely secondary to previous heavy oral antibiotics. Pain: No abdominal pain currently. 4. Current Treatment Protocol (Started at Home): Targeted Therapy for CML: Tab Imatinib 400mg (OD) Antibiotics for Infection (Aggressive IV approach): - Inj Meropenem 1gm IV (TDS - administered via 100ml NS drip) Inj Amikacin 750mg IV (OD - administered via 100ml NS slow infusion over 30-45 mins, strict instruction given to avoid direct IV push) Sachet Fosfomycin 3gm (Weekly) Supportive Medications: Tab Febuxostat 40mg (OD) - To manage uric acid levels. Tab Ecosprin 75mg (BD) - For high platelets. Cap Pentate LS / Esomac-L (BD) - For gastric protection and nausea prevention. Tab Eltroxin 50mcg (OD - empty stomach) - Pre-existing thyroid medication. Tab Paracetamol 650mg (Strictly SOS - only if fever crosses 100°F). Medications Stopped: We have completely discontinued her previous oral antibiotics (Loxof 500, Nitrofurantoin) and Hydroxyurea (Hydrozest 500) as per the new treatment plan. Could you please review her complete history and current treatment approach? I would highly appreciate your insights on whether this current line of aggressive treatment is optimal, or if any additional precautions/changes are required while managing her at home. Thank you for your time and guidance.