Can I have surgery while on estradiol for gender transition, or do I need to stop taking it due to blood clot risks? - #29171
I am 52 year old male to female transgender. I am on 4 mg of estradiol a day and have been for four months. Can I have surgery while on the meds or do I need to come off of the estradiol first being the risk factor of blood clots?
What type of surgery are you considering?:
- Other surgical proceduresHave you had any previous surgeries while on estradiol?:
- No, this is my first surgeryHave you experienced any side effects from estradiol?:
- Mild side effectsDo you have any history of blood clots or related conditions?:
- Yes, previous blood clotsHow long have you been on estradiol?:
- 1-4 monthsHave you discussed your medication with your surgeon?:
- No, not yetAre you currently taking any other medications?:
- Yes, prescribed medications100% Anonymously
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Doctors' responses
Hello
Yes, you can have surgery while taking estrogen, but in your case the decision needs extra caution because you have a history of blood clots, which significantly increases risk during surgery.
The medication involved is Estradiol, and estrogen can raise the chance of developing another clot, especially around surgery when mobility is reduced and the body is under stress. Because you are 52 years old and have had previous clots, most surgeons and anesthesiologists will consider you higher risk.
In many situations like yours, doctors commonly recommend temporarily stopping estradiol about 2–4 weeks before surgery and restarting it after you are fully mobile, unless the surgery is urgent. They may also use preventive measures such as blood thinners, compression stockings, and early walking after the procedure. However, the exact plan depends on the type of surgery, how long it will last, and your individual clot history.
The most important next step is to inform your surgeon and anesthesiologist as soon as possible that you are taking estradiol and that you have had prior blood clots. Do not stop the medication on your own until they give instructions, because timing and coordination with the surgical team matters.
Bottom line: surgery is still possible, but with your prior clot history, there is a higher likelihood that your team will advise pausing estrogen temporarily and using clot-prevention strategies to keep you safe.
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