What is the best anti-aging medication based on evidence? - #29787

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If i ask you to give me drug for anti ageing. What would you give me ? And why ? According to all evidence?

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Dr. Bharat Joshi

I’m a periodontist and academician with a strong clinical and teaching background. Over the last 4 years and 8 months, I’ve been actively involved in dental education, guiding students at multiple levels including dental hygienist, BDS, and MDS programs. Currently, I serve as a Reader at MMCDSR in Ambala, Haryana—a role that allows me to merge my academic passion with hands-on experience. Clinically, I’ve been practicing dentistry for the past 12 years. From routine procedures like scaling and root planing to more advanced cases involving grafts, biopsies, and implant surgeries. Honestly, I still find joy in doing a simple RCT when it’s needed. It’s not just about the procedure but making sure the patient feels comfortable and safe. Academically, I have 26 research publications to my credit. I’m on the editorial boards of the Archives of Dental Research and Journal of Dental Research and Oral Health, and I’ve spent a lot of time reviewing manuscripts—from case reports to meta-analyses and even book reviews. I was honored to receive the “Best Editor” award by Innovative Publications, and Athena Publications recognized me as an “excellent reviewer,” which honestly came as a bit of a surprise! In 2025, I had the opportunity to present a guest lecture in Italy on traumatic oral lesions. Sharing my work and learning from peers globally has been incredibly fulfilling. Outside academics and clinics, I’ve also worked in the pharmaceutical sector as a Drug Safety Associate for about 3 years, focusing on pharmacovigilance. That role really sharpened my attention to detail and deepened my understanding of drug interactions and adverse effects. My goal is to keep learning, and give every patient and student my absolute best.

4 hours ago

Hello dear
See right now there is proven medication with evidence and research
However some medication do impact on life but they are proven only in disease
Metformin antidiabetic and slows Cancer cells
Reserve trol inhibits  hmp shunt
Rapaymycin impact ageing cells
However preventive measures are also required
Exercise
Diet control
Avoidance of junk food and alcohol
Anti stress environment
Good habits
Regards

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Dr. Arsha K Isac

I am a general dentist with 3+ years of working in real-world setups, and lemme say—every single patient teaches me something diff. It’s not just teeth honestly, it’s people… and how they feel walking into the chair. I try really hard to not make it just a “procedure thing.” I explain stuff in plain words—no confusing dental jargon, just straight talk—coz I feel like when ppl *get* what's going on, they feel safer n that makes all the difference. Worked with all ages—like, little kids who need that gentle nudge about brushing, to older folks who come in with long histories and sometimes just need someone to really sit n listen. It’s weirdly rewarding to see someone walk out lighter, not just 'coz their toothache's gone but coz they felt seen during the whole thing. A lot of ppl come in scared or just unsure, and I honestly take that seriously. I keep the vibe calm. Try to read their mood, don’t rush. I always tell myself—every smile’s got a story, even the broken ones. My thing is: comfort first, then precision. I want the outcome to last, not just look good for a week. Not tryna claim perfection or magic solutions—just consistent, clear, hands-on care where patients feel heard. I think dentistry should *fit* the person, not push them into a box. That's kinda been my philosophy from day one. And yeah, maybe sometimes I overexplain or spend a bit too long checking alignment again but hey, if it means someone eats pain-free or finally smiles wide in pics again? Worth it. Every time.

2 hours ago

Hello
There isn’t a single “best” anti-aging drug, but the strongest overall evidence in humans supports topical tretinoin. It consistently improves wrinkles, pigmentation, and skin texture by increasing collagen production and normalizing skin cell turnover, with decades of controlled studies behind it.
For systemic (whole-body) aging, no medication is definitively proven to slow aging in healthy people; drugs like metformin and rapamycin are still being researched and are not recommended purely for anti-aging outside clinical settings.
So, based on current evidence, tretinoin is the most reliable choice—because it has clear, reproducible human data showing measurable reversal of visible aging changes.
Regards
Feel free to talk

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Dr. Prasannajeet Singh Shekhawat

I am a 2023 batch passout and working as a general physician right now, based in Hanumangarh, Rajasthan. Still kinda new in the bigger picture maybe, but honestly—every single day in this line teaches you more than textbooks ever could. I’ve had the chance to work under some pretty respected doctors during and after my graduation, not just for the clinical part but also to see how they handle people, real people, in pain, in panic, and sometimes just confused about their own health. General medicine covers a lot, right? Like from the smallest complaints to those random, vague symptoms that no one really understands at first—those are kinda my zone now. I don’t really rush to label things, I try to spend time actually listening. Feels weird to say it but ya, I do take that part seriously. Some patients just need someone to hear the whole story instead of jumping to prescription pads after 30 seconds. Right now, my practice includes everything from managing common infections, blood pressure issues, sugar problems to more layered cases where symptoms overlap and you gotta just... piece things together. It's not glamorous all the time, but it's real. I’ve handled a bunch of seasonal disease waves too, like dengue surges and viral fevers that hit rural belts hard—Hanumangarh doesn’t get much spotlight but there’s plenty happening out here. Also, I do rely on basics—thorough history, solid clinical exam and yeah when needed, investigations. But not over-prescribing things just cz they’re there. One thing I picked up from the senior consultants I worked with—they used to say “don’t chase labs, chase the patient’s story”... stuck with me till now. Anyway, still learning every single day tbh. But I like that. Keeps me grounded and kind of obsessed with trying to get better.

1 hour ago

Hello
Here’s a friendly breakdown:
### 1. Topical Treatments
- Retinoids (Retinol): These are vitamin A derivatives that promote cell turnover, improve skin texture, and reduce fine lines and wrinkles. They stimulate collagen production and can help with pigmentation issues.
- Vitamin C (Ascorbic Acid): A powerful antioxidant that helps brighten the skin, reduce pigmentation, and protect against UV damage. It also aids in collagen synthesis.
- Hyaluronic Acid: A hydrating ingredient that helps retain moisture in the skin, making it look plumper and reducing the appearance of fine lines.
- Peptides: These are short chains of amino acids that can help stimulate collagen production and improve skin elasticity.
### 2. Chemical Exfoliants
- Alpha Hydroxy Acids (AHAs): Such as glycolic acid, which helps exfoliate the skin, improve texture, and promote a more youthful appearance.
- Beta Hydroxy Acids (BHAs): Such as salicylic acid, which can help with acne and improve skin texture.
### 3. Sunscreen
- Broad-Spectrum SPF: Daily use of sunscreen is crucial in preventing premature aging caused by sun exposure. Look for a broad-spectrum sunscreen with at least SPF 30.
### 4. Lifestyle Factors
- Healthy Diet: A diet rich in antioxidants, vitamins, and minerals can support skin health. Foods like berries, nuts, leafy greens, and fatty fish are great choices.
- Hydration: Drinking enough water helps maintain skin hydration and elasticity.
- Avoid Smoking and Limit Alcohol: Both can accelerate the aging process and damage skin health.
### 5. Professional Treatments
- Chemical Peels: These can help improve skin texture and reduce signs of aging.
- Microneedling: This treatment stimulates collagen production and can improve the appearance of fine lines and wrinkles.
- Laser Treatments: Various laser therapies can target pigmentation, texture, and overall skin rejuvenation.
### Conclusion
While these ingredients and treatments have evidence supporting their effectiveness in anti-aging, it’s essential to consult with a dermatologist to determine the best approach for your specific skin type and concerns. They can provide personalized recommendations based on your skin’s needs and any underlying conditions.
Thank you

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